The San Fierro Highway starts at an intersection on the Mulholland Drive in northern Rodeo, and immediately enters a tunnel passing underneath Richman. When it nears Las Venturas, it turns and heads west towards its starting point, while staying in Red County the second time around, which makes it a looped highway. Then, after clearing the docks and a few residential home (by way of traffic lights) it becomes a freeway again, on the other side of Red County. The expressway ends briefly in Ocean Docks and becomes a major road through East Beach. Near the airport, for a short time, the median has two guard rails on each side keeping traffic to their own side, this is due to a tunnel upon which the freeway must encounter.

It begins at the Montgomery Intersection in Red County, and travels south through the Mulholland Intersection, Downtown, and then the airport. The Los Santos Freeway is the longest highway in San Andreas and is modeled after Interstate 15. Highways included in the system Major Highways Los Santos Freeway The minor highways include the East Beach Freeway Extension, Santa Maria Freeway Extension and Harry Gold Parkway. The five major highways include the Julius Thruway, Los Santos Freeway, San Fierro Highway, San Fierro Bypass and Las Venturas Highway. The San Andreas highway system encompasses five major highways, four minor highways, and four other routes.